Books and Book Chapters

    Toxicological Evaluation of Electronic Nicotine Delivery Products

    Date published
    Jan 14, 2021
    DOI
    10.1016/C2019-0-02209-1
    ISBN
    978-0-12-820490-0
    Published in
    Toxicological Evaluation of Electronic Nicotine Delivery Products
    Editors
    Peitsch, M. C.; Hoeng, J.
    Link to publication
    Topic
    Summary

    Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.

    Table of Contents:

    1. Tobacco Harm Reduction
    2. Electronic nicotine delivery devices (ENDS)
    3. The scientific basis for the assessment of ENDS
    4. Quantification of HPHC in ENDS aerosols
    5. Aerosol physics and dynamics
    6. Advanced analytical chemistry methods to characterize ENDS aerosols
    7. Other species of toxicological concern
    8. Impact of ENDS on indoor air quality
    9. A systems-based approach to toxicity testing
    10. Translational aspects of toxicity testing
    11. Dosimetry and human-relevant exposure
    12. Aerosol generation, exposure, and collection
    13. Toxicological assessment in vitro
    14. Toxicological assessment in vivo
    15. Assessment of in vivo models of disease
    16. Flavors and their toxicological assessment
    17. A clinical strategy for ENDS testing
    18. The disease risk reduction potential of ENDS
    19. Residual risk associated to nicotine
    20. Conclusion
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    Reduced Risk Products ("RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continuing smoking. PMI has a range of RRPs in various stages of development, scientific assessment and commercialization. All of our RRPs are smoke-free products that deliver nicotine with far lower quantities of harmful and potentially harmful constituents than found in cigarette smoke.